The Truth About Peptides in Skincare
September 2025
Do Peptides Live Up to All the Hype – and Should You Use Them?
If you feel like everyone is hyper-focused on peptides lately, it’s not in your imagination. This buzzword is showing up everywhere from skincare commercials to Instagram reels as the powerful anti-aging treatment that can smooth fine lines and improve skin health.
This article takes a closer look at peptides, how they work, what results you can expect, and when to talk to your dermatologist so you can be skin smart about incorporating peptides into your skincare routine.
What Are Peptides in Skincare?
Not to be confused with the peptides that are being touted as a weight-loss supplement (both are chains of amino acids but serve different and distinct functions), peptides in skincare are short chains of the amino acids that support production of the skin’s naturally occurring proteins, collagen and elastin.
Collagen and elastin are essential for helping the skin appear youthful, firm, and smooth; however, as we age, natural production of collagen and elastin declines, leading to fine lines, wrinkles, and sagging skin.
The widespread desire to combat signs of aging and reclaim our younger, fresher faces has driven demand for skincare products like peptides that claim to do just that: peptides in skincare are designed to send signals to the skin that encourage collagen and elastin production.
Different peptides may target different concerns, so whether you’re looking for greater firmness or an improved skin barrier, there is a peptide formula for you. Some of the products our providers recommend and carry at various Optima Dermatology locations include:
- Alastin’s Restorative Skin Complex
- Revision’s Revox Line Relaxer
- ZO’s Daily Power Defense
- SkinBetter’s Alto Defense Serum
The Big Question: Do Peptides Really Work?
Research suggests that peptides can be effective, especially when used consistently and in the right formulation. According to research published in the National Library of Medicine, peptides are promising active ingredients with unique anti-aging properties, and studies demonstrate their efficacy in products used to improve signs of aging. While this research does note the need for further research on the full potential of peptides, it’s clear enough that consumer desire for these products isn’t unfounded.
The most marketed benefits of peptides include:
- Enhancing skin hydration, creating a smoother and more supple appearance
- Stimulating collagen production to improve firmness and reduce fine lines.
- Supporting the skin barrier, which helps retain moisture and protect against irritants.
- Reducing inflammation, which may improve overall skin tone and texture.
Despite these compelling points, it’s important to note that peptides aren’t an instant fix – and may not produce desired results for several weeks or even months of consistent use.
If you work with your dermatologist to identify the best peptide formula for your skin, you’ll be able to establish expectations for results and understand more about your specific treatment.
Are Peptides Safe?
Peptide safety is an important question for many people before they begin use. For most people, peptides are considered safe and are generally well-tolerated and non-irritating – even by individuals with sensitive skin.
However, as with any skincare product, it’s best to introduce peptides gradually and monitor your skin’s response.
For individuals with mild or severe allergies, who already use prescription skincare, or are undergoing treatments like chemical peels or laser therapy, we advise you to check with your dermatologist before starting a peptide product – or any new product for that matter.
Using Peptides Correctly for Best Results
If you’re interested in trying peptides, here are a few tips to help you maximize their benefits:
Look for serums and creams. Peptides work best when applied as leave-on products. This way, they have plenty of time to absorb into the skin.
Use consistently. Apply once or twice daily, as directed. Remember, it may take several weeks or months to notice changes.
Combine wisely. Peptides pair well with ingredients like hyaluronic acid, niacinamide, and antioxidants. Avoid layering them directly with strong acids or retinoids, which can reduce their effectiveness and could cause skin irritation or dryness.
Be realistic. Peptides can support healthier, more youthful-looking skin, but they won’t have the same impact as more advanced treatments like Botox, fillers, or laser and light therapies if you’re looking for more significant results.
It’s easy to get swept up in the buzz around products that promise to reverse aging naturally, but like anything, it’s important to do your homework before immediately buying into the hype.
Peptides can be a great addition to a skincare routine, but they’re also only one part of a bigger picture. Your dermatologist or provider can design a personalized skincare routine based on your skin type and your specific goals.
At Optima Dermatology, we specialize in helping you achieve your healthiest skin with a combination of medical-grade skincare, cosmetic treatments, and professional guidance.
Request an appointment to speak with one of our expert providers about the right peptide – or other – treatment to achieve your skin goals.