Understanding Autoimmune Skin Disorders


The Skin and Autoimmune Connection That Patients Need to Know
We’re back with another Derm Deep Dive, a series where we provide expert advice from our board-certified dermatologists about common skin conditions or treatments. This month, we sought input from our team of expert dermatologists to share information and guidance about autoimmune skin disorders – specifically what they are, how they manifest, and what you can do if you develop one.
Being Aware of Autoimmune Skin Disorders
As our body’s protective barrier, the skin is responsible for a lot, including raising the red flag if there is a deeper, systemic health concern we should be aware of – like autoimmune skin disorders.
Often, we don’t know how to interpret what’s going on with our skin. It can be hard to distinguish eczema from psoriasis, or acne from rosacea, as many signs and symptoms can be similar. When we get unexplained rashes, persistent irritation, or other chronic skin issues, it can be easy to ignore it or hope it goes away, but you should pay attention and seek help as these symptoms can signal underlying autoimmune skin disorders.
When the Immune System Takes Aim at the Skin
Autoimmune skin disorders happen when the body’s immune system mistakenly attacks healthy skin cells, typically causing inflammation, skin damage, or other types of irritation on the skin.
The skin is good at indicating deeper, more systemic health issues, and recognizing and responding to these signs early ensures timely intervention and better long-term outcomes.
We’re going to explain some of the most common types of autoimmune skin disorders and the symptoms that you should look out for.
Cutaneous Lupus
Cutaneous lupus (CLE) specifically attacks the skin, unlike systemic or erythematosus lupus, which attacks organs and other systems in the body. While it affects the skin, cutaneous lupus can be a manifestation of systemic lupus.
CLE symptoms, which include rashes, sores, and lesions on the skin, are often triggered by sun exposure. These systems can manifest in specific ways:
- A butterfly-shaped rash across the cheeks and nose
- Discoid lesions that leave scars
- Sores in the mouth or nose
Since sun exposure is a trigger, UV protection is essential at managing cutaneous lupus. Because CLE is an autoimmune skin disorder with no known cure, treatment is focused on managing symptoms, preventing flare ups, and minimizing long-term skin damage. Specific management plans may include a combination of lifestyle changes, topical and systemic medications, and in some cases, specialized therapies.
Psoriasis and Psoriatic Arthritis
Psoriasis is caused by an overactive immune system in which the growth of skin cells occurs very quickly. Normal skin cells take about a month to finish growing and to be shed from the body, while skin cells impacted by psoriasis finish growing every few days and pile up on the surface of the skin instead of shedding.
There are different types of psoriasis, the most common being plaque psoriasis, which manifests as raised patches of skin called plaques that are typically itchy, red, inflamed, and often appear to have silvery scales or even a dark coloration, depending on skin type.
Other types of psoriasis include:
- Inverse psoriasis, which lacks the scaly appearance and typically manifests under the breasts, armpits, or in the genital and buttocks areas.
- Guttate psoriasis, which typically manifests as small red spots, and is frequently found on the arms, legs, chest, stomach, or back.
- Pustular psoriasis, which is characterized by pus-filled bumps that are painful and irritated. While it often appears on the hands and feet, it can manifest anywhere on the body.
- Erythrodermic psoriasis, which is very rare and causes redness and such excessive shedding of skin layers that it can be life-threatening. Symptoms include itching and pain, an almost burned appearance of the skin, as well as more serious conditions such as changes in heart rate or dehydration.
Very rarely, individuals with psoriasis can develop psoriatic arthritis, which can cause symptoms of arthritis in the joints.
Psoriasis can flare up when the immune system reacts to a trigger, such as illness, stress, exposure to hot or cold temperatures, contact with an allergen, or even trauma to the skin, such as a burn or scrape.
Broadly, symptoms of psoriasis typically include:
- Thick, scaly patches (plaques) on the elbows, knees, scalp, and lower back
- Nail pitting or discoloration
- Patches or bumps that are itchy and do not heal on their own
Treatment is focused on reducing inflammation and flare ups through the slowing of skin cell growth and scale removal. If psoriasis symptoms are more mild, it may be effectively managed with topical treatments, while more severe cases may require phototherapy or systemic medications.
Dermatomyositis
This rare, inflammatory disease affects the skin and muscles. It’s characterized by muscle weakness, pain, and a distinctive skin rash. The rash can appear on sun-exposed areas like the face, eyelids, knuckles, and chest.
While the exact cause of dermatomyositis is unknown, it’s believed to involve a combination of genetic predisposition and environmental triggers, such as sun exposure or certain medications.
Symptoms of dermatomyositis can include:
- Violet or dusky red rash, especially on the face, eyelids, knuckles, and chest
- Muscle weakness
- Photosensitivity
While there is no known treatment for dermatomyositis, management of this autoimmune skin disorder focuses on reducing inflammation and improving muscle strength and function. Your dermatologist may prescribe medications like corticosteroids, immunosuppressants, or other immunomodulatory treatments.
Scleroderma
Scleroderma causes hardening and tightening of the skin due to excess collagen production.
Like other autoimmune skin disorders, there is no specific cause of scleroderma, but it has been loosely linked to genetic predisposition, environmental triggers, hormonal imbalances, or immune system dysfunction.
Skin symptoms may include:
- Thickened patches of skin
- Shiny or tight skin, especially on the hands and face
- Raynaud’s phenomenon (color changes in fingers/toes with cold exposure)
There is no definitive cure for scleroderma, but treatments are focused on preventing deeper complications from the disorder. Treatment plans are tailored to the individual depending on severity, but can include medications, physical therapy, or lifestyle modifications.
Cutaneous Vasculitis
Cutaneous vasculitis is a type of vasculitis in which inflammation can damage blood vessel walls, leading to leakage of red blood cells into the surrounding skin and causing purpura (bruising).
Other skin symptoms can include:
- Blisters or hive-like lesions
- Purplish spots or patches (often on the legs)
- Ulcers or open sores
- Bruise-like rashes that don’t fade
Treatment for vasculitis primarily involves medications to control inflammation. More severe cases may require immunosuppressants or biologics to calm the immune system and prevent further damage to blood vessels and organs. In some cases, surgery may be necessary to repair damaged blood vessels.
Lichen Planus
Like the other skin conditions in this post, there is no known cause for lichen planus, an autoimmune skin disorder that causes the immune system to target the cells lining the skin, mucous membranes, and other organs, leading to inflammation and the development of characteristic lesions.
This condition has been linked to genetic and environmental factors that may trigger an autoimmune response, and other triggers are thought to include medications, infections, or allergies.
Symptoms of lichen planus can include:
- Flat-topped, itchy, purple-colored bumps
- White, lacy patches inside the mouth
- Nail thinning or ridging
Unlike the other skin conditions in this post, lichen planus often resolves on its own. However, treatment is focused on managing symptoms of inflammation and itchiness through the use of topical corticosteroids. More severe cases may require systemic treatments. Dermatologists also recommend good oral hygiene and reducing stress as methods for managing lichen planus.
Pay Attention to Red Flags That May Be Signaling Something More
While rashes, itching, and other changes to the skin are common and can vary by season or activity, certain signs may be an indicator of an autoimmune disorder. Visit your board-certified dermatologist if you notice:
- Rashes that don’t respond to typical treatments such as corticosteroids or antifungals
- Joint pain accompanying skin symptoms like swelling, stiffness, or decreased mobility
- Nail changes or scalp involvement, such as pitting, ridging, hair loss, or scarring
- Photosensitivity or systemic symptoms, including unexplained fatigue, low-grade fevers, or general malaise
Dermatology and Rheumatology Collaborations
While dermatologists specialize in diagnosing and treating conditions of the skin, hair, and nails, and addressing conditions affecting the mucous membranes in and around the nose, mouth, and eyelids, rheumatologists specialize in diagnosing and treating conditions that affect the musculoskeletal system, including the joints, muscles, and bones.
Many autoimmune skin conditions require a collaborative approach between dermatologists and rheumatologists, and your dermatologist may make a referral to a rheumatologist depending on the type and severity of your autoimmune skin disorder.
When We Refer and Why: Our dermatologists may refer you to rheumatology when skin symptoms suggest systemic involvement, such as joint pain or fatigue. Rheumatologists often refer back to dermatology for persistent or unusual rashes.
Diagnostic Tools: Biopsies help confirm a dermatologic diagnosis by examining skin tissue under a microscope. Rheumatologic testing can identify systemic inflammation or specific autoimmune patterns.
Coordinated Treatment Plans: Treating autoimmune skin conditions often involves long-term care and collaboration between dermatologists and rheumatologists.
Shared Treatments: Both dermatologists and rheumatologists may prescribe biologics or immunosuppressants to control immune activity. Treatment plans are tailored based on the extent and location of symptoms.
Managing Expectations: Many autoimmune skin diseases are chronic and relapsing, meaning symptoms may flare even with treatment. If you are suffering from an autoimmune skin disorder, you would benefit most from consistent follow-up and the open communication between your dermatologist and rheumatologist.
Your skin may be trying to tell you something. If you’re experiencing unexplained rashes, persistent skin issues, or symptoms that suggest an autoimmune condition, don’t wait. There is a complex relationship between autoimmune disease and skin health, and early evaluation can make a significant difference in diagnosis and treatment.
At Optima Dermatology, our experienced providers work closely with referring specialists to ensure you receive the care you need.
We’re here to help you, listen to you – and take action. Schedule an appointment with one of our providers to discuss your skin concerns.